Functional correlations between lateral hypothalamic glucose-sensitive neurons and hepatic portal glucose-sensitive units in rat

Brain Res. 1983 Apr 11;265(1):49-54. doi: 10.1016/0006-8993(83)91332-x.

Abstract

The effects of glucose injection into the hepatic portal vein on neural activity of the lateral hypothalamic area (LHA) were studied in rats. A majority of identified glucose-sensitive neurons in the LHA were inhibited by portal injection of glucose. This was found to be mediated through the alpha-noradrenergic pathways. Most of the glucose-insensitive neurons did not respond to the same procedure. Portal injection of hypertonic saline increased neural activity of some glucose-insensitive neurons but no glucose-sensitive neurons responded. Convergence of hepatic vagal afferent glucose-sensitive units on LHA glucose-sensitive neurons was clarified by this study.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Afferent Pathways / physiology
  • Animals
  • Blood Glucose / physiology*
  • Brain Mapping
  • Chemoreceptor Cells / physiology
  • Female
  • Hypothalamic Area, Lateral / physiology*
  • Liver / innervation*
  • Male
  • Norepinephrine / physiology
  • Portal Vein
  • Rats
  • Rats, Inbred Strains
  • Vagus Nerve / physiology*

Substances

  • Blood Glucose
  • Norepinephrine