Neuroblastoma associated with Beckwith-Wiedemann syndrome

Cancer. 1983 Jul 1;52(1):176-9. doi: 10.1002/1097-0142(19830701)52:1<176::aid-cncr2820520132>3.0.co;2-v.

Abstract

This report describes an infant with Beckwith-Wiedemann Syndrome (BWS) found to have a thoracic neuroblastoma. Infants with BWS are known to have an increased incidence of tumors (10%). We believe this to be the first report of a malignant neural crest tumor in a child with BWS and also the first case occurring in familial BWS. Usually the malignancies associated with the BWS are intraabdominal; however, this malignancy was located in the chest. It is important to detect malignancy in early stages. Therefore, recommendations for screening children with BWS are discussed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Beckwith-Wiedemann Syndrome / complications*
  • Humans
  • Infant, Newborn
  • Male
  • Neuroblastoma / complications*
  • Neuroblastoma / congenital
  • Neuroblastoma / pathology
  • Pancreas / pathology
  • Thoracic Neoplasms / complications*
  • Thoracic Neoplasms / congenital
  • Thoracic Neoplasms / pathology