Diflunisal disposition and hypouricemic response in osteoarthritis

Clin Pharmacol Ther. 1983 Jun;33(6):813-21. doi: 10.1038/clpt.1983.111.


The disposition of diflunisal was studied at daily doses of 250, 500, 750, 1000 mg/day in 24 male patients (mean age 65 yr and mean creatinine clearance 72 ml/min). Each dose was given for 14 days and diflunisal apparent oral clearance and serum urate was measured on the last day of each dosing regimen. There was a dose-dependent decrease in mean diflunisal apparent oral clearance with dose from 628 ml/hr at 250 mg/day to 426 ml/hr at 1000 mg/day, with most of the decrease occurring at the lower doses and becoming less pronounced at doses of 750 and 1000 mg/day. There was a strong positive correlation between diflunisal apparent oral clearance and creatinine clearance. Diflunisal induced a hypouricemic effect at all doses, but the responses at doses of 750 and 1000 mg/day did not differ.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Chromatography, High Pressure Liquid
  • Creatinine / blood
  • Diflunisal / metabolism*
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis / metabolism*
  • Salicylates / metabolism*
  • Uric Acid / blood


  • Salicylates
  • Uric Acid
  • Diflunisal
  • Creatinine