Guinea pig maximization test: Podophyllum lignans

Contact Dermatitis. 1983 Mar;9(2):95-8. doi: 10.1111/j.1600-0536.1983.tb04313.x.


The guinea pig maximization test was used to study the sensitizing potential of Podophyllum lignans; 0.5% of each drug in propylene glycol was used for induction and 0.01%, 0.05%, 0.1% and 0.5% preparations for topical challenge. The 0.1% and 0.5% preparations caused non-allergic toxic reactions associated with the cutaneous destructive influence of these drugs; allergic responses did not occur.

MeSH terms

  • Animals
  • Guinea Pigs
  • Irritants*
  • Podophyllotoxin / analogs & derivatives*
  • Podophyllotoxin / toxicity
  • Skin Tests


  • Irritants
  • Podophyllotoxin