[Effect of turkesterone and nerobol on the activity of the protein synthesizing system of mouse liver]

Vopr Med Khim. 1978 Jul-Aug;24(4):456-60.
[Article in Russian]


Protein biosynthesis was stimulated in liver tissue in vivo and in vitro after administration into mice of either phytoecdizone of turkesterone (0.5 mg/100 g) or of anabolic steroid compound nerobole (1 mg/100 g). Stimulation of protein biosynthesis was due to an increase in functional activity of polyribosomes and to elevation in the synthesis of protein molecules. Actinomycin D, which inhibited the stimulation of protein biosynthesis in liver tissue of mice treated with nerobole, did not affect the phenomenon in mice treated with turkesterone.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cell-Free System
  • Dactinomycin / pharmacology
  • Ecdysterone / analogs & derivatives
  • Female
  • Leucine / metabolism
  • Liver / drug effects*
  • Methandrostenolone / pharmacology*
  • Mice
  • Polyribosomes / drug effects
  • Protein Biosynthesis* / drug effects
  • RNA, Messenger / biosynthesis
  • Stimulation, Chemical
  • Valine / metabolism


  • RNA, Messenger
  • Dactinomycin
  • Ecdysterone
  • turkesterone
  • Methandrostenolone
  • Leucine
  • Valine