Microsomal and cytosolic epoxide hydrolases in rhesus monkey liver, and in normal and neoplastic human liver

Life Sci. 1983 Jun 6;32(23):2693-700. doi: 10.1016/0024-3205(83)90362-4.


The cytosolic epoxide hydrolase (EH-LC) was observed in rhesus monkey liver cytosol, and in both normal and neoplastic human liver. Microsomal epoxide hydrolase (EH-LM) was detected not only in the microsomes of normal and neoplastic human liver and normal rhesus monkey liver, but also in the cytosol of these tissues. No apparent differences were observed between the EH-LM in liver cytosol and that in microsomes. No major differences were observed between the levels of EH-LM in the cytosol of normal and that in neoplastic human liver.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cytosol / enzymology
  • Epoxide Hydrolases / metabolism*
  • Female
  • Humans
  • Infant
  • Liver / enzymology*
  • Liver Neoplasms / enzymology*
  • Macaca mulatta
  • Male
  • Microsomes, Liver / enzymology
  • Middle Aged
  • Species Specificity
  • Stilbenes / metabolism
  • Styrenes / metabolism
  • Tissue Distribution


  • Stilbenes
  • Styrenes
  • beta-ethylstyrene oxide
  • Epoxide Hydrolases
  • stilbene oxide