Consumptive coagulopathy. A complication of therapy of solid tumors in childhood

Am J Dis Child. 1978 Sep;132(9):870-2.


The association of consumptive coagulopathy and malignancy is thought to be rare in pediatrics. In one patient with Ewing's sarcoma and in two with rhabdomyosarcoma consumptive coagulopathy developed in the presence of either diffuse metastatic disease or an extensive primary tumor. The coagulopathy was a major clinical problem, developing within five days of the onset of chemotherapy. Resolution coincided with the clinical response of the tumor.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / etiology*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Infant
  • Male
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Remission, Spontaneous
  • Rhabdomyosarcoma / drug therapy*
  • Sarcoma, Ewing / drug therapy*


  • Antineoplastic Agents