Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 146 (3), 316-22

Long-term Effect of Megestrol Acetate in the Treatment of Endometrial Hyperplasia

Long-term Effect of Megestrol Acetate in the Treatment of Endometrial Hyperplasia

D Gal et al. Am J Obstet Gynecol.

Abstract

Fifty-two postmenopausal women who were poor surgical risks and had histologically proved adenomatous hyperplasia, atypical hyperplasia, or adenocarcinoma in situ of the endometrium were treated with megestrol acetate, 40 mg per day, continuously for 9 to 104 months (mean, 42 months). More than 90% of these women had complete remissions of the hyperplasia. Three women with carcinoma in situ were followed up for 57, 65, and 104 months, without recurrence of the disease. Four women required hysterectomy; none had invasive adenocarcinoma. No adverse side effects of the drug were observed. Thus, we conclude that the continuous use of megestrol acetate is an effective, safe, alternative form of therapy for endometrial hyperplasia in postmenopausal women.

Similar articles

  • Progestin Therapy in Lesions of the Endometrium
    WB Wentz. Semin Oncol 12 (1 Suppl 1), 23-7. PMID 3975648.
    This paper details several studies of the effect of a single progestin, megestrol acetate, in patients with persistent endometrial hyperplasia and recurrent or persistent …
  • Hormonal Therapy for Lesions of the Endometrium
    D Gal. Semin Oncol 13 (4 Suppl 4), 33-6. PMID 3798126.
    Megestrol acetate, 20 to 40 mg/d, was given continuously to 70 postmenopausal women with a variety of endometrial hyperplastic changes. All patients were followed up with …
  • Megestrol Acetate: Clinical Experience
    L Schacter et al. Cancer Treat Rev 16 (1), 49-63. PMID 2471590. - Review
    The use of megestrol acetate in treatment of malignancy (endometrial carcinoma, ovarian cancer, prostate cancer, breast cancer, renal cell carcinoma, malignant melanoma), …
  • Hyperglycemia Secondary to Megestrol Acetate for Endometrial Neoplasia
    PG Rose. Gynecol Oncol 61 (1), 139-41. PMID 8626102. - Case Reports
    Two patients with endometrial neoplasia developed severe hyperglycemia secondary to megestrol acetate. Patients who receive progestational therapy with megestrol acetate …
  • [Therapy of Advanced Endometrial Cancer]
    H Okada et al. Gan To Kagaku Ryoho 17 (9), 1848-55. PMID 2144105. - Review
    In recent years, the incidence of endometrial cancer has a tendency to increase gradually in our country. Its majority (stage I and II) is a case to be treated by hystere …
See all similar articles

Cited by 6 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback