Interfollicular Hodgkin's disease

Am J Surg Pathol. 1983 Mar;7(2):145-9. doi: 10.1097/00000478-198303000-00004.


An unusual pattern of focal involvement of lymph nodes by Hodgkin's disease is described which we have named "interfollicular Hodgkin's disease." It is characterized by florid reactive follicular hyperplasia which overshadows involvement of the interfollicular zones by Hodgkin's disease. The pattern can be mistakenly diagnosed as one of the many causes of reactive follicular hyperplasia. The seven cases studied did not appear to differ clinically from other more recognizable forms of Hodgkin's disease. The importance of this pattern of lymph node involvement by Hodgkin's disease rests on its misdiagnosis as a benign lesion and not on any unusual clinical features.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Diagnosis, Differential
  • Female
  • Hodgkin Disease / diagnosis
  • Hodgkin Disease / pathology*
  • Humans
  • Hyperplasia / diagnosis
  • Hyperplasia / pathology
  • Lymph Nodes / pathology*
  • Male
  • Middle Aged