Macrophage function in pulmonary alveolar proteinosis

Am Rev Respir Dis. 1983 Jun;127(6):780-1. doi: 10.1164/arrd.1983.127.6.780.


We studied the lavage fluid recovered from a symptomatic patient with pulmonary alveolar proteinosis using in vitro assays for macrophage function. The alveolar macrophages from this patient had reduced phagocytic capacity. The particulate fraction from the cell-free lavage fluid (20,000 X gravity pellet) induced a pronounced phagocytic defect in normal mouse peritoneal macrophages but did not impair intracellular degradative activity. These results suggest that the lipoproteinaceous debris in patients with alveolar proteinosis can induce a phagocytic defect in alveolar macrophages, which probably increases the accumulation of more debris and may contribute to the increased risk of pulmonary infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Humans
  • Macrophages / physiology*
  • Male
  • Phagocytosis
  • Pulmonary Alveolar Proteinosis / physiopathology*
  • Pulmonary Alveoli / physiopathology