Abstract
The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.
MeSH terms
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Animals
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Antineoplastic Agents / toxicity*
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Aristolochic Acids*
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Hyperplasia
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Male
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Neoplasms, Experimental / chemically induced
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Papilloma / chemically induced
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Phenanthrenes / toxicity*
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Rats
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Rats, Inbred Strains
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Stomach / pathology
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Stomach Neoplasms / chemically induced*
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Stomach Neoplasms / pathology
Substances
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Antineoplastic Agents
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Aristolochic Acids
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Phenanthrenes
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aristolochic acid I