The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations

Am J Obstet Gynecol. 1978 Jul 15;131(6):665-71. doi: 10.1016/0002-9378(78)90829-3.


Cytogenetic and morphologic analysis of 23 hydatidiform moles allowed the division into at least two syndromes: (1) the syndrome of complete (classical) mole is without an ascertainable embryo/fetus, gives a diploid karyotype, and manifests a progressive fluid engorgement of the villi as well as a gross, haphazardly distributed trophoblastic hyperplasia; (2) the syndrome of partial (incomplete) mole has an ascertainable fetus (alive or dead), gives a triploid karyotype, and exhibits a slowly progressing hydatidiform swelling in the presence of functioning villous capillaries that spares many villi; trophoblastic immaturity is constant and focal hyperplasia is inconspicuous but present. A single case of diploid mole with unusual morphologic features, complete with a fetus, may herald yet another syndrome. Human chorionic gonadotropin levels were initially high in practically all cases. There was no malignant trophoblastic disease in this small series, but a plea is made that partial moles be followed carefully in order to establish their relation to choriocarcinoma.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Chorionic Gonadotropin / metabolism
  • Chorionic Villi / pathology
  • Diploidy
  • Female
  • Humans
  • Hydatidiform Mole* / classification
  • Hydatidiform Mole* / genetics
  • Hydatidiform Mole* / pathology
  • Hyperplasia
  • Karyotyping
  • Polyploidy
  • Pregnancy
  • Syndrome
  • Trophoblasts / pathology
  • Uterine Neoplasms* / classification
  • Uterine Neoplasms* / genetics
  • Uterine Neoplasms* / pathology


  • Chorionic Gonadotropin