Interaction of penicillins with the components of plasma expanders

Drug Intell Clin Pharm. 1983 May;17(5):351-6. doi: 10.1177/106002808301700506.

Abstract

The interaction of penicillin with high molecular components of plasma expander such as dextran, 6-hydroxyethylstarch, and polygeline were studied. The formation of penicilloyl polysaccharides and smaller amounts of penicilloyl polygeline during incubation were confirmed by ultrafiltration and gelfiltration. The ultrafiltration through Collodion-Bags SM 13 200 was found to be a rapid and convenient method for the determination of macromolecular penicilloates. The accelerated degradation by the formation of penicilloyl esters with glucose and lactic acid was also suggested.

MeSH terms

  • Drug Interactions
  • Drug Stability
  • Penicillins*
  • Plasma Substitutes*

Substances

  • Penicillins
  • Plasma Substitutes