Identification of the major urinary metabolites of (+)-catechin and 3-O-methyl-(+)-catechin in man

Eur J Drug Metab Pharmacokinet. 1983;8(1):77-84. doi: 10.1007/BF03189584.

Abstract

Following oral administration of (+)-catechin and 3-O-methyl-(+)-catechin to human volunteers the major urinary metabolites were shown to be the glucuronides of 3'-O-methyl-(+)-catechin respectively. Isolations from urine and from synthetic products have been carried out by semi-preparative high performance liquid chromatography; definitive elucidations of structures have been carried out by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.

MeSH terms

  • Benzopyrans / urine*
  • Biotransformation
  • Catechin / analogs & derivatives
  • Catechin / urine*
  • Chromatography, High Pressure Liquid / methods
  • Gas Chromatography-Mass Spectrometry / methods
  • Humans
  • Magnetic Resonance Spectroscopy
  • Methylation

Substances

  • Benzopyrans
  • meciadanol
  • Catechin