Pharmacokinetics of diltiazem after intravenous and oral administration

Eur J Clin Pharmacol. 1983;24(3):349-52. doi: 10.1007/BF00610053.

Abstract

The kinetic profile of diltiazem, a novel calcium antagonist, was studied in 12 volunteers following oral (60 mg) and intravenous (15 mg) administration. After i.v. administration biphasic elimination was observed, with a distribution half-life of 0.3 +/- 0.2 h and an elimination half-life of 3.1 +/- 1.0 h; the apparent volume of distribution was 5.3 +/- 1.71/kg and the total clearance was 1.28 +/- 0.48 l/kg/h. After the oral dose the elimination had a half-life of 3.2 +/- 1.3 h. The absolute bioavailability of diltiazem ranged from 24 to 74% (mean 42 +/- 18%). The interindividual variation may be explained by a variable first pass effect.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adult
  • Benzazepines / metabolism*
  • Biological Availability
  • Diltiazem / administration & dosage
  • Diltiazem / metabolism*
  • Half-Life
  • Humans
  • Infusions, Parenteral
  • Kinetics

Substances

  • Benzazepines
  • Diltiazem