Relationships between plasma theophylline clearance, liver volume and body weight in children and adults

Eur J Clin Pharmacol. 1983;24(4):529-32. doi: 10.1007/BF00609898.


The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults. A linear relationship (r = +0.99) was demonstrated between ideal body weight and liver volume estimated by an ultrasonic scanning technique. Age-related changes in liver volume-to-body weight ratio could account for only 30% of differences in plasma theophylline clearance (1/h/kg) between children and adults. It is summized that increased hepatic mixed function oxidase activity is the major contributor to the higher plasma theophylline clearance in children.

MeSH terms

  • Adult
  • Aging
  • Body Weight*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Liver / anatomy & histology
  • Liver / physiology*
  • Male
  • Middle Aged
  • Organ Size
  • Theophylline / blood*
  • Ultrasonics


  • Theophylline