Sebaceous carcinoma of the eyelid following radiation therapy

Am J Surg Pathol. 1978 Sep;2(3):305-11. doi: 10.1097/00000478-197809000-00007.


This paper reports a case of a 12-year-old boy with fatal sebaceous carcinoma originating from the eyelid. The carcinoma developed 11 years after curative radiation therapy for bilateral retinoblastoma. Sebaceous carcinomas associated with previous irradiation are uncommon, and only five such cases have been published. Three of the patients were treated for benign disorders and the two other cases followed radiation therapy for bilateral retinoblastoma. Second malignant neoplasms in patients with bilateral retinoblastoma are thought to be related to a genetically inherited predisposition to the development of second malignant tumors. Radiation therapy is claimed to be an inducing factor in many cases but malignant neoplasms are also found in areas distant from the portals of irradiation as well as in patients not irradiated. Most of the secondary tumors were sarcomas, and usually osteogenic sarcomas.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Carcinoma / etiology
  • Carcinoma / pathology*
  • Carcinoma / ultrastructure
  • Child
  • Child, Preschool
  • Eye Neoplasms / radiotherapy
  • Eyelid Neoplasms / etiology
  • Eyelid Neoplasms / pathology*
  • Eyelid Neoplasms / ultrastructure
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary
  • Radiotherapy / adverse effects*
  • Retinoblastoma / radiotherapy
  • Sebaceous Gland Neoplasms / etiology
  • Sebaceous Gland Neoplasms / pathology*
  • Sebaceous Gland Neoplasms / ultrastructure