In vitro and in vivo evaluation of two preparations of activated charcoal as adsorbents of aspirin

Hum Toxicol. 1983 Apr;2(2):211-6. doi: 10.1177/096032718300200206.


1 The adsorptive capacities of two preparations of activated charcoal have been studied both in vitro and in vivo using aspirin as a test compound. 2 The in vitro adsorptive capacities of the charcoal preparations were 477 mg of acetylsalicylic acid/g effervescent charcoal ('Medicoal'); 359 mg/g untreated standard charcoal ('Norit-A') and 482 mg/g reheated charcoal ('Norit A'). 3 In vivo both charcoal preparations significantly reduced peak salicylate concentrations and salicylate availability, to a similar extent (analysis of variance P less than 0.001). 4 Both charcoal preparations have similar capacities for adsorbing aspirin both in vitro and in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Adult
  • Aspirin / poisoning*
  • Biological Availability
  • Charcoal / therapeutic use*
  • Female
  • Humans
  • Male
  • Salicylates / blood
  • Salicylic Acid
  • Time Factors


  • Salicylates
  • Charcoal
  • Salicylic Acid
  • Aspirin