A comparison of a disposable membrane filtration system with a direct inoculation system for the sterility testing of veterinary biologics

J Biol Stand. 1983 Apr;11(2):83-9. doi: 10.1016/s0092-1157(83)80030-4.


A direct inoculation method for sterility testing veterinary biologics was compared with a closed membrane filtration method (Steritest). The filtration method detected extraneous contamination in 29% more batches of biologics than the direct inoculation method. Live viral biologics produced in cell culture were found to be the only product type that could be filtered; hence the filtration method cannot be recommended universally as a replacement for the direct inoculation method.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biological Products / standards*
  • Filtration
  • Sterilization / standards*
  • Veterinary Medicine*
  • Viral Vaccines / standards


  • Biological Products
  • Viral Vaccines