A cell-surface molecule involved in organ-specific homing of lymphocytes

Nature. 1983 Jul 7-13;304(5921):30-4. doi: 10.1038/304030a0.


Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antigen-Antibody Complex
  • Antigens, Surface / analysis
  • Cell Adhesion
  • Cell Line
  • Endothelium / immunology
  • Humans
  • Lymphocytes / immunology*
  • Lymphoma / immunology
  • Mice
  • Molecular Weight
  • Neoplasms / immunology
  • Phenotype
  • Rats


  • Antibodies, Monoclonal
  • Antigen-Antibody Complex
  • Antigens, Surface