Search for heterozygosis in quantitative characters

Ann Hum Genet. 1978 Jul;42(1):121-8. doi: 10.1111/j.1469-1809.1978.tb00936.x.

Abstract

A method is described of searching for heterozygotes in a quantitative character, based on the idea that heterozygotes have more variable children than homozygotes. The variability in a set of sibs is therefore partitioned into components from the mother and father, using a least squares technique; a large component indicates a probably heterozygous parent. The method is tried out on dermatoglyphic data.

MeSH terms

  • Dermatoglyphics
  • Female
  • Genetics, Medical*
  • Heterozygote*
  • Humans
  • Male
  • Mathematics
  • Models, Biological*