The role of the GSH-disulfide status in the reversible and irreversible aggregation of human platelets

Thromb Res. 1983 Apr 15;30(2):137-42. doi: 10.1016/0049-3848(83)90236-0.

Abstract

Disturbance of cellular SH/SS status of blood platelets by diminution of the level of reduced glutathione is very sensitively reflected in changes of the in vitro aggregation. Additionally, disulfide-linked protein polymers are formed. One of these polymers participates in mediating platelet disaggregation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / pharmacology*
  • Diamide / pharmacology*
  • Glutathione / analogs & derivatives*
  • Glutathione / metabolism
  • Glutathione Disulfide
  • Humans
  • In Vitro Techniques
  • Iodoacetamide / pharmacology*
  • Iodoacetates / pharmacology*
  • Platelet Aggregation / drug effects*
  • Time Factors

Substances

  • Azo Compounds
  • Iodoacetates
  • Diamide
  • Glutathione
  • Glutathione Disulfide
  • Iodoacetamide