Potential oxidative pathways of catecholamines in the formation of lipid peroxides and genesis of heart disease

Adv Exp Med Biol. 1983;161:391-401. doi: 10.1007/978-1-4684-4472-8_22.

Abstract

Effects of vitamin E, a fat soluble antioxidant, on the isoproterenol-induced changes in the lipid peroxide activity as determined by a quantitation of malondialdehyde (MDA) content in the myocardium were examined. Isoproterenol treatment (80 mg/kg given over two days in two equal doses) caused more than 100 percent increase in the MDA content which was prevented by pretreatment of the animals with vitamin E (alpha-tocopherol acetate, 10 mg/kg) for two weeks. Animals maintained on vitamin E deficient diet for 8 weeks were found to be more sensitive to isoproterenol-induced increase in the MDA content. A small increase in MDA content was also seen due to vitamin E deficiency alone. These changes were found to be reversible upon a 2 week feeding of the animals on the normal diet coupled with vitamin E treatment. Based on these data it is proposed that free radical mediated increase in lipid peroxide activity may have a role in catecholamine-induced heart disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / analysis
  • Animals
  • Arrhythmias, Cardiac / chemically induced
  • Cardiomyopathies / drug therapy
  • Cardiomyopathies / etiology*
  • Cardiomyopathies / metabolism
  • Catecholamines / metabolism*
  • Isoproterenol / administration & dosage
  • Lipid Peroxides / biosynthesis*
  • Male
  • Malondialdehyde / analysis
  • Myocardium / ultrastructure
  • Oxygen Consumption*
  • Phosphocreatine / analysis
  • Rats
  • Rats, Inbred Strains
  • Vitamin E / administration & dosage

Substances

  • Catecholamines
  • Lipid Peroxides
  • Phosphocreatine
  • Vitamin E
  • Malondialdehyde
  • Adenosine Triphosphate
  • Isoproterenol