Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis

Agents Actions. 1983 Apr;13(2-3):255-7. doi: 10.1007/BF01967346.


The CSF of twenty-six patients with multiple sclerosis (MS) and of twelve control persons was analysed for histamine and histamine-N-methyltransferase (HMT) activity. Both in patients with remitting and progressive type of disease the histamine level was about 60% higher than in the controls. On the other hand in both groups of patients the HMT activity was significantly lower (32% and 40% respectively) than that of controls. These results suggest an altered histamine metabolism in MS. This might be associated with the immune reaction in MS brain.

MeSH terms

  • Adolescent
  • Adult
  • Histamine / cerebrospinal fluid*
  • Histamine N-Methyltransferase / cerebrospinal fluid*
  • Humans
  • Methyltransferases / cerebrospinal fluid*
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / enzymology


  • Histamine
  • Methyltransferases
  • Histamine N-Methyltransferase