Arrhythmias and left ventricular function after defibrillation during acute myocardial infarction in the intact dog

Am Heart J. 1983 Aug;106(2):292-9. doi: 10.1016/0002-8703(83)90195-3.


The purpose of this study was to assess the recovery of the left ventricular pressure (PLV), and the incidence and type of arrhythmias after effective low-dose defibrillation (Imax = 18-70 A) in healthy hearts and in hearts with acute myocardial infarction (AMI) in the intact dog. In fifteen dogs 84 episodes of fibrillation-defibrillation were studied in the healthy heart and 53 episodes were studied in the acute phase of myocardial infarction 1/2 to 3 hours after occlusion of a part of the left anterior descending artery by a catheter technique. Time to recovery of PLV depended on duration of fibrillation (tF) and cumulative defibrillation current (I 1/2), and became critical at tF greater than 45 seconds and I 1/2 greater than 45 A. Total duration of arrhythmias due to defibrillation increased with increasing tF and I 1/2. Arrhythmias which have a relative greater chance of resulting in refibrillation or which may seriously decrease the cardiac output occurred more often with I 1/2 greater than 55 A (p less than 0.001), when 50% of episodes were followed by these arrhythmias. No differences were found in responses between the healthy heart and the heart with AMI.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / etiology*
  • Blood Pressure
  • Dogs
  • Electric Countershock / adverse effects*
  • Electrocardiography
  • Fatty Acids, Nonesterified / blood
  • Heart Massage
  • Heart Ventricles / physiopathology*
  • Lactates / blood
  • Myocardial Infarction / blood
  • Myocardial Infarction / physiopathology*
  • Systole
  • Time Factors


  • Fatty Acids, Nonesterified
  • Lactates