The non-specific enhancement of allergy. I. In vivo effects of Bordetella pertussis vaccine on IgE synthesis

Allergy. 1983 May;38(4):239-46. doi: 10.1111/j.1398-9995.1983.tb01617.x.


Bordetella pertussis organisms, with or without a small dose of alumhydroxide, enhance in rats the production of IgE antibodies to an unrelated antigen, even if this antigen has been administered 6 weeks beforehand. This non-specific enhancement of IgE antibodies is accompanied by a substantial rise in total serum IgE and by the production of IgE antibodies to B. pertussis. The effect of B. pertussis on IgE synthesis is dose-dependent. No effect of B. pertussis on IgE production can be observed in nude rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Aluminum Hydroxide / administration & dosage
  • Aluminum Hydroxide / immunology
  • Animals
  • Antibody Specificity
  • Disease Models, Animal
  • Dose-Response Relationship, Immunologic
  • Immunoglobulin E / analysis
  • Immunoglobulin E / biosynthesis*
  • Ovalbumin / immunology
  • Pertussis Vaccine / administration & dosage*
  • Pertussis Vaccine / immunology
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred Strains
  • Rats, Mutant Strains
  • Respiratory Hypersensitivity / immunology*


  • Adjuvants, Immunologic
  • Pertussis Vaccine
  • Immunoglobulin E
  • Aluminum Hydroxide
  • Ovalbumin