The clinical course of end-stage renal disease in systemic lupus erythematosus

Arch Intern Med. 1983 Jul;143(7):1353-6.


Despite treatment advances, renal failure still develops in patients with systemic lupus erythematosus (SLE). With the common use of long-term maintenance hemodialysis, this complication is no longer fatal. In order to evaluate factors that contribute to the outcome of patients with SLE receiving long-term hemodialysis, we retrospectively analyzed the clinical course of 14 patients with SLE receiving hemodialysis for more than three months, and compared them with 62 patients receiving long-term hemodialysis who did not have SLE. While receiving long-term hemodialysis, SLE activity was minimal, with most manifestations involving the CNS or synovitis. Five-year survival was significantly lower in the SLE than in the non-SLE group (58.6% v 88.5%), but no deaths were directly attributable to SLE activity. Morbidity in the SLE group was primarily due to infection and vascular access problems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Kidney Failure, Chronic / etiology*
  • Kidney Failure, Chronic / therapy
  • Lupus Erythematosus, Systemic / complications*
  • Outcome and Process Assessment, Health Care
  • Prognosis
  • Renal Dialysis
  • Retrospective Studies
  • Time Factors