Sodium balance and antidiuresis in thiazide-treated rats with diabetes insipidus

Eur J Pharmacol. 1983 May 6;89(3-4):283-6. doi: 10.1016/0014-2999(83)90507-1.


A sodium deficit was induced in Brattleboro rats by lowering the dietary sodium content. Urine volume was only slightly reduced. Addition of hydrochlorothiazide to the food caused a small, transient sodium deficit but led to a marked, sustained antidiuresis. The acute administration of a large dose of hydrochlorothiazide produced a larger, sustained sodium deficit but no lasting antidiuresis. These results indicate that sodium depletion cannot account for the antidiuresis of hydrochlorothiazide treatment in diabetes insipidus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Diabetes Insipidus / drug therapy
  • Diabetes Insipidus / metabolism*
  • Diet, Sodium-Restricted
  • Diuresis / drug effects*
  • Hydrochlorothiazide / adverse effects
  • Hydrochlorothiazide / therapeutic use*
  • Male
  • Natriuresis / drug effects*
  • Rats
  • Rats, Brattleboro
  • Sodium / deficiency


  • Hydrochlorothiazide
  • Sodium