Blood-group-I activity associated with band 3, the major intrinsic membrane protein of human erythrocytes

Biochem J. 1978 Jul 1;173(1):333-6. doi: 10.1042/bj1730333.

Abstract

Affinity chromatography of radioiodinated solubilized erythrocyte stroma and of radioiodinated purified Band 3 on an anti-(blood-group I)-adsorbent column showed blood-group-I activity associated with a subpopulation of Band 3. The specificity of binding was confirmed by inhibition with known blood-group substances in radioimmunoassays.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Group Antigens*
  • Chromatography, Affinity
  • Electrophoresis, Polyacrylamide Gel
  • Erythrocyte Membrane / immunology*
  • Erythrocytes / immunology*
  • Humans
  • I Blood-Group System*
  • Membrane Proteins / immunology*

Substances

  • Blood Group Antigens
  • I Blood-Group System
  • Membrane Proteins