Clones of MRC-C cells may be superior to the parent line for the culture of 229E-like strains of human respiratory coronavirus

J Virol Methods. 1983 May;6(5):267-9. doi: 10.1016/0166-0934(83)90041-1.


A clone was selected from the MRC-C continuous heteroploid cell line which was significantly better than MRC-C for the culture of human respiratory coronavirus (HCV) 229E, strain LP. Such clones could prove generally useful for the isolation of HCV-229E from clinical specimens, and for the propagation and assay of laboratory adapted strains.

Publication types

  • Comparative Study

MeSH terms

  • Clone Cells / microbiology*
  • Coronaviridae / isolation & purification*
  • Embryo, Mammalian
  • Humans
  • Lung
  • Virus Cultivation / methods*