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. 1983 Jun;72(6):705-7.
doi: 10.1002/jps.2600720630.

NMR Studies and GC Analysis of the Antibacterial Agent Taurolidine

NMR Studies and GC Analysis of the Antibacterial Agent Taurolidine

B I Knight et al. J Pharm Sci. .

Abstract

The NMR spectrum of taurolidine in deuterium oxide was compared with spectra obtained from model experiments with amines and formaldehyde. Head-space analysis combined with capillary GC showed that there was less than 0.004% free formaldehyde present in 2% solutions of taurolidine. This value is comparable to the concentration of formaldehyde found when the taurolidine solutions were injected directly onto GC columns.

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