Acute toxicity after excessive ingestion of colchicine

Mayo Clin Proc. 1983 Aug;58(8):528-32.


A 15-year-old girl was admitted to a hospital in Rochester, Minnesota, 40 hours after the ingestion of 24 mg of colchicine. She suffered severe cardiovascular, pulmonary, hematologic, gastrointestinal, renal, metabolic, and neuromuscular complications but ultimately survived. Colchicine is an uncommon but potentially serious source of acute toxicity. An overdose warrants prompt attention in a setting where intensive medical support is available.

Publication types

  • Case Reports

MeSH terms

  • Acidosis / chemically induced
  • Adolescent
  • Bone Marrow / drug effects
  • Cardiovascular System / drug effects
  • Colchicine / poisoning*
  • Digestive System / drug effects
  • Female
  • Humans
  • Kidney / drug effects
  • Nervous System / drug effects
  • Respiration / drug effects


  • Colchicine