Patulin biosynthesis: enzymatic and nonenzymatic transformations of the mycotoxin (E)-ascladiol

Appl Environ Microbiol. 1983 Jun;45(6):1939-42. doi: 10.1128/aem.45.6.1939-1942.1983.

Abstract

A mycotoxin, (E)-ascladiol, was established as a direct precursor of patulin in cell-free preparations of Penicillium urticae patulin-minus mutants J1 and S11, but not S15. Isomerization to a side product, (Z)-ascladiol, was nonenzymatically catalyzed by sulfhydryl compounds.

MeSH terms

  • Cell-Free System
  • Furans / analysis
  • Furans / metabolism*
  • Isomerism
  • Mycotoxins / analysis
  • Mycotoxins / metabolism*
  • NADP / metabolism
  • Patulin / biosynthesis*
  • Penicillium / enzymology
  • Penicillium / metabolism*
  • Pyrans / biosynthesis*
  • Spectrum Analysis
  • Sulfhydryl Compounds / pharmacology

Substances

  • Furans
  • Mycotoxins
  • Pyrans
  • Sulfhydryl Compounds
  • ascladiol
  • NADP
  • Patulin