Cancer Treat Rep. 1978 Aug;62(8):1251-3.


A new class of potential chemotherapeutic agents consisting of steroids coupled with nucleoside bases is described. Such structures may be viewed as nucleosides in which the sugar moiety is replaced by a steroid molecule. We may therefore expect the nucleoside characteristics to give interference at the DNA level, resulting in the desired antitumor activity, whereas the steroid moiety may provide target specificity. A number of such coupling products were prepared and preliminary biologic studies are reported.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / therapeutic use
  • Female
  • Leukemia L1210 / drug therapy
  • Mice
  • Nucleosides / chemical synthesis*
  • Nucleosides / metabolism
  • Nucleosides / pharmacology
  • Rats
  • Rats, Inbred F344
  • Receptors, Steroid / metabolism
  • Steroids / chemical synthesis*
  • Steroids / metabolism
  • Steroids / pharmacology


  • Antineoplastic Agents
  • Nucleosides
  • Receptors, Steroid
  • Steroids