Computerized histopathologic assessment of malignant potential. II. A practical method for predicting survival following enucleation for uveal melanoma

Cancer. 1983 Sep 15;52(6):1032-8. doi: 10.1002/1097-0142(19830915)52:6<1032::aid-cncr2820520618>;2-b.


To assess the malignant potential of uveal melanomas from standard histopathologic material, a single microslide from each of 100 cases underwent computer-assisted measurement of nucleolar cross-sectional area. The standard deviation of 200 measurements per slide correlated well with survival of patients following enucleation for their ocular tumor. Furthermore, a statistical model calculated from these measurements effectively predicted survival for 50 additional cases. Additional investigation demonstrated the following features of this method: (1) a high level of reproducibility; (2) acceptable constancy among different levels of the same tumor; (3) a practical expenditure of resources (assessment of each case required less than 40 minutes of a technician's time and an apparatus costing approximately $20,00). This method--computerized histopathologic assessment of malignant potential (CHAMP)--thus provides the pathologist with a practical method for extracting prognostic information from standard H & E-stained microslides of uveal melanomas. Previous studies by other researchers suggests that a similar method might be effective in assessing the malignant potential of more common neoplasms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autopsy
  • Biopsy
  • Cell Nucleolus / pathology
  • Cell Nucleus / pathology
  • Computers*
  • Humans
  • Melanoma / pathology*
  • Melanoma / surgery
  • Probability
  • Prognosis
  • Registries
  • Uveal Neoplasms / pathology*
  • Uveal Neoplasms / surgery