Hemorheological effects of pentoxifylline on disturbed flow behavior of blood in patients with cerebrovascular insufficiency

Eur Neurol. 1983;22 Suppl 1:105-7. doi: 10.1159/000115658.

Abstract

The influence of pentoxifylline (11-18 mg/kg orally, Trental 400) on impaired hemorheologic conditions has been investigated in a total of 73 patients with CVI. Throughout a treatment period of 4 weeks, there was a significant improvement in red cell behavior and a significant inhibition of increased platelet aggregation; moreover, a fall in plasma fibrinogen and of blood viscosity has also been observed.

MeSH terms

  • Adenosine Diphosphate / antagonists & inhibitors
  • Blood Viscosity
  • Cerebrovascular Disorders / blood
  • Cerebrovascular Disorders / drug therapy*
  • Epinephrine / antagonists & inhibitors
  • Erythrocytes / physiology
  • Female
  • Fibrinogen / analysis
  • Humans
  • Male
  • Middle Aged
  • Pentoxifylline / therapeutic use*
  • Platelet Aggregation / drug effects
  • Rheology
  • Theobromine / analogs & derivatives*

Substances

  • Adenosine Diphosphate
  • Fibrinogen
  • Theobromine
  • Pentoxifylline
  • Epinephrine