Alterations in state in apneic pre-term infants receiving theophylline

Clin Pharmacol Ther. 1978 Oct;24(4):474-8. doi: 10.1002/cpt1978244474.


The present study is a report on 9 premature infants treated with aminophylline for relief of apnea. With serum theophylline levels of 2 to 10 microgram/ml, all infants experienced significant decrease of apneic episodes in association with increased wakefulness and increased amounts of active (REM) sleep. These effects may occur independently, but it is possible that the alteration of sleep states may be partially responsible for the decrease in apneic episodes in these infants.

MeSH terms

  • Aminophylline / therapeutic use
  • Apnea / drug therapy
  • Apnea / physiopathology*
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / drug therapy
  • Infant, Premature, Diseases / physiopathology*
  • Sleep / physiology
  • Sleep Stages / drug effects*
  • Theophylline / pharmacology*
  • Theophylline / therapeutic use


  • Aminophylline
  • Theophylline