Of 45 female inpatients with schizophrenia, depression, borderline personality, or depression and borderline personality, 28 met criteria for probable or definite premenstrual affective syndrome. Of these 28, 16 had abnormal sexual histories, compared with only 1 of the 17 women who did not have premenstrual affective syndrome. Of the 12 patients with both depression and borderline personality disorder, 9 had both premenstrual affective syndrome and abnormal sexual histories. The 6 patients who had been raped all met the criteria for premenstrual affective syndrome. The authors suggest that premenstrual affective syndrome may signify unresolved sexual conflicts in subgroups of psychiatric patients.