Complete clinical remission was achieved in a very large lymphocytic thymoma with infiltration of both lungs and almost complete atelectasis of the left lung as well as superior vena cava syndrome using adriamycin (80 mg/m2, day 1) and cis-platinum (120 mg/m2, day 1). A dramatic reduction of tumour size was noticed already after the first cycle of chemotherapy. Remission still persists nine months after commencement of treatment.