Dosimetry in isolation perfusion of the limbs by assessment of perfused tissue volume and grading of toxic tissue reactions

Eur J Cancer Clin Oncol. 1982 Oct;18(10):905-10. doi: 10.1016/0277-5379(82)90235-8.


The optimal single dosage of melphalan in isolation perfusion of the limbs for malignant melanoma was assessed. For this purpose a method to determine the volume of the isolated region in the individual patient and a grading system for the reaction of the normal tissues were introduced. A strictly standardized pharmacosurgical routine was developed that permitted an analysis of the correlation between dosage and the grade of toxic reaction in 90 perfusions. The optimal dosage of a cytostatic drug was considered to be the highest amount tolerated at an acceptable risk. Melphalan at 10 mg/l perfused tissue was determined as the likely optimum. This dose provoked remarkably little variation in toxicity, all reactions falling within a safe range. No exception to the applicability of this dosage was encountered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arm
  • Body Weight
  • Chemotherapy, Cancer, Regional Perfusion*
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Extremities*
  • Humans
  • Leg
  • Melanoma / drug therapy*
  • Melphalan / administration & dosage*
  • Melphalan / adverse effects
  • Melphalan / therapeutic use


  • Melphalan