Elastic tissue changes in skin following PUVA therapy

J Am Acad Dermatol. 1980 Aug;3(2):186-92. doi: 10.1016/s0190-9622(80)80258-1.

Abstract

Treatment of psoriasis with psoralens and high-intensity long-wave ultraviolet light (PUVA) produces changes in the ultrastructure of elastic tissue in skin. Early alterations consist of a loss of elastin followed by a breakdown of the microfibrils and subsequent fragmentation of the elastic fiber. Tissue examined 15 months after treatment was stopped still showed marked ultrastructural changes in the elastic fibers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Elastic Tissue / drug effects*
  • Elastic Tissue / ultrastructure
  • Elastin / analysis
  • Furocoumarins / pharmacology*
  • Photochemotherapy*
  • Psoriasis / drug therapy
  • Skin / drug effects*
  • Skin / ultrastructure

Substances

  • Furocoumarins
  • Elastin