Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity

J Antibiot (Tokyo). 1980 Sep;33(9):940-5. doi: 10.7164/antibiotics.33.940.

Abstract

A novel antitumor antibiotic complex has been obtained from the culture broth of Actinomycete strain DO-11 (KY11091) isolated from a soil sample collected in Sendai, Miyagi, Japan. On the taxonomic studies the producing organism is described as Micromonospora chalcea KY11091. For the production of the antibiotics, soluble starch served as a good carbon source and yeast extract was the best nitrogen source tested. The antibiotic complex designated as tetrocarcins is active against Gram-positive bacteria, but is not active against Gram-negative bacteria. Tetrocarcin A showed bacteriocidal activity against Bacillus subtilis.

MeSH terms

  • Aminoglycosides*
  • Anti-Bacterial Agents*
  • Antibiotics, Antineoplastic / biosynthesis*
  • Antibiotics, Antineoplastic / pharmacology
  • Bacteria / drug effects
  • Fermentation
  • Glycosides / biosynthesis
  • Glycosides / pharmacology
  • Micromonospora / metabolism*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Glycosides
  • tetrocarcin A
  • tetrocarcin C
  • tetrocarcin B