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, 67 (2-3), 313-6

Intrathecal Morphine in Mice: A New Technique

Intrathecal Morphine in Mice: A New Technique

J L Hylden et al. Eur J Pharmacol.


A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

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