Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 67 (2-3), 313-6

Intrathecal Morphine in Mice: A New Technique

Intrathecal Morphine in Mice: A New Technique

J L Hylden et al. Eur J Pharmacol.

Abstract

A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.

Similar articles

See all similar articles

Cited by 402 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback