The primary structure of porcine glicentin (proglucagon)

Regul Pept. 1981 May;2(2):139-50. doi: 10.1016/0167-0115(81)90007-0.


The primary structure of porcine glicentin has been established. The molecule consists of 69 amino acid residues and has a molecular weight of 8128. The sequence of glicentin 1-30 represents the glicentin-related pancreatic peptide (GRPP) previously isolated from porcine pancreas. The sequence 33-61 represents the full sequence of glucagon and the sequence 64-69 is a C-terminal hexapeptide. These three sequences, GRPP, glucagon and the hexapeptide are linked by two Lys-Arg pairs which probably represent the sites for post-synthetic enzymatic cleavages. Glicentin thus fulfils the structural requirements for being proglucagon.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Glicentin
  • Glucagon*
  • Glucagon-Like Peptides
  • Models, Chemical
  • Molecular Weight
  • Pancreas / analysis*
  • Peptide Fragments
  • Peptides*
  • Proglucagon
  • Protein Precursors*
  • Swine / metabolism*


  • Peptide Fragments
  • Peptides
  • Protein Precursors
  • Proglucagon
  • Glucagon-Like Peptides
  • Glicentin
  • glicentin-related pancreatic peptide
  • glucagon-like-immunoreactivity
  • Glucagon