Cardiovascular effects of leukotriene D4 in SHR and WKY rats

Eur J Pharmacol. 1981 Nov 19;76(1):107-10. doi: 10.1016/0014-2999(81)90017-0.


Leukotriene D4 (LTD4, 0.8-4 micrograms/kg i.a.) increased blood pressure and heart rate of conscious SHR and WKY rats. LTD4, 20 micrograms/kg (i.a.), caused a short lasting increase in blood pressure and heart rate in WKY. In SHR, LTD4, 20 micrograms/kg (i.a.) caused a triphasic effect: hypotension and bradycardia (0.5-1 min), hypertension and tachycardia (2-5 min) and prolonged hypotension and bradycardia (5-180 min). Leukopenia was observed after LTD4, 20 micrograms/kg in both groups of rats but platelets count was unaffected. These results show that SHR are mor sensitive than WKY to the hypotension-bradycardia effect of LTD4.

MeSH terms

  • Animals
  • Blood Pressure / drug effects*
  • Consciousness / physiology
  • Heart Rate / drug effects*
  • Hypertension / drug therapy
  • Hypertension / physiopathology*
  • Leukocyte Count
  • Leukopenia / chemically induced
  • Rats
  • Rats, Inbred Strains
  • SRS-A / pharmacology*


  • SRS-A