Abstract
Twenty-one patients with various forms of myoclonus are presented. Phenacemide was given to five patients with considerable benefit to three, but with serious toxic effects in two. Another acetylurea derivative, pheneturide, was given to 19 patients and was well tolerated. Myoclonus was completely or substantially controlled in 12 patients.
MeSH terms
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Adolescent
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Adult
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Cerebellar Ataxia / complications
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Cerebellar Ataxia / drug therapy
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Drug Evaluation
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Epilepsy / complications
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Epilepsy / drug therapy
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Female
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Humans
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Male
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Middle Aged
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Myoclonus / complications
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Myoclonus / drug therapy*
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Phenylbutyrates / administration & dosage
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Phenylbutyrates / adverse effects
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Phenylbutyrates / therapeutic use
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Urea / administration & dosage
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Urea / adverse effects
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Urea / analogs & derivatives*
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Urea / therapeutic use
Substances
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Phenylbutyrates
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pheneturide
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Urea