In vitro antiplaque properties of a series of alkyl bis(biguanides)

J Med Chem. 1978 Aug;21(8):828-9. doi: 10.1021/jm00206a024.


A series of eight alkyl bis(biguanide) analogues of alexidine, N,N''''-1,6-hexanediyl bis[N'-(2-ethylhexyl)imidodicarbonimidic diamide] (1), was prepared. Five of these analogues constituted a series isolipophilic with 1 but with varying bridge length between biguanide moieties. The compounds were evaluated in vitro for antibacterial and antiplaque properties against Streptococcus mutans, Actinomyces viscosus, and Actinomyces naesludii. One analogue, N N,''''-1,6-hexanediyl bis[N'(n-octyl)imidodicarbonimidic diamide], appeared to be more effective than either 1 or chlorhexidine against this spectrum of dental plaque forming microorganisms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actinomyces / drug effects
  • Biguanides / chemical synthesis*
  • Biguanides / pharmacology
  • Biguanides / therapeutic use
  • Dental Plaque / prevention & control*
  • Streptococcus mutans / drug effects


  • Biguanides