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Clinical Trial
. 1982;13(3):182-4.
doi: 10.1007/BF00205385.

A Follow-Up Study on Chemoimmunotherapy (5-fluorouracil and BCG) in Advanced Gastric Cancer

Clinical Trial

A Follow-Up Study on Chemoimmunotherapy (5-fluorouracil and BCG) in Advanced Gastric Cancer

T Popiela et al. Cancer Immunol Immunother. .


Two hundred and seventeen patients with advanced gastric cancer were classified according to the resectability of the tumour into two groups: I, resectable (non-radical surgery), 99 patients, and II, non-resectable carcinoma, 118 patients. Within each group patients were randomly assigned to receive 5-fluorouracil (5-FU) + BCG, 5-FU, or no further treatment (surgery only). BCG was given by scarification. A 2-year follow-up is reported. The group of patients with resectable tumours and receiving chemoimmunotherapy had a statistically significant prolongation of survival compared with the 5-FU and surgery only groups. No differences in survival were observed between these treatment modalities in patients with non-resectable tumour. These observations indicate that chemoimmunotherapy may be of benefit for a selected group of patients with gastric cancer.

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