Anticaries and Antiplaque Potential of Free-Fatty Acids in Vitro and in Vivo

Pharmacol Ther Dent. 1980;5(1-2):25-33.


The efficacy of several fatty acids as antimicrobial, antiplaque, and anticaries agents, as well as their ability to inhibit hydroxyapatite dissolution were examined. All effectively inhibited bacterial growth. Lauric, linoleic, and oleic acids decreased plaque formation and lauric acid inhibited hydroxyapatite dissolution. When used in the food, lauric acid decreased caries in rats, but not significantly.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacteria / drug effects
  • Cariostatic Agents*
  • Dental Enamel Solubility / drug effects
  • Dental Plaque / etiology*
  • Fatty Acids, Nonesterified / administration & dosage
  • Fatty Acids, Nonesterified / pharmacology*
  • Female
  • Food Additives / pharmacology
  • Hydroxyapatites
  • Male
  • Mouthwashes / pharmacology
  • Rats


  • Cariostatic Agents
  • Fatty Acids, Nonesterified
  • Food Additives
  • Hydroxyapatites
  • Mouthwashes