Complement fixing antibody responses to virus infection in children with acute lymphoblastic leukaemia

J Clin Pathol. 1980 Aug;33(8):735-7. doi: 10.1136/jcp.33.8.735.


Thirty children with acute lymphoblastic leukaemia (ALL) were studied and had a virus isolated. Only 50% produced a significant rise in complement fixing (CF) antibody titre compared to 100% of normal children. The failure to produce antibodies was unpredictable. CF antibodies are not a reliable guide to virus infections in children with ALL.

MeSH terms

  • Acute Disease
  • Adolescent
  • Antibodies, Viral / biosynthesis*
  • Child
  • Child, Preschool
  • Complement Fixation Tests
  • Female
  • Humans
  • Leukemia, Lymphoid / immunology*
  • Male
  • Virus Diseases / immunology*


  • Antibodies, Viral